Mouse Monoclonal Antibody to CD4

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别名:CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4
应用:IHC
反应种属:Human,Rat,Mouse
规格：50μl/100μl

Description
Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC).

Description

Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC).

Specification
Aliases	CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4
Entrez GeneID	920
Swissprot	P01730
clone	6B10
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat,Mouse
Immunogen	Synthetic peptide conjugated to KLH.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IHC	1/50-1/100

	Immunofluorescence analysis of CD4 in mouse colon tissue using CD4 antibody(11A1)(red),and DAPI (blue).
	Immunofluorescence analysis of CD4 in rat lung using CD4 antibody(11A1)(red),and DAPI (blue).
	Immunohistochemistry analysis of paraffin-embedded Human stomach tissue using CD4 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Negative control was used by secondary antibody only.
	Immunohistochemical analysis of paraffin-embedded Human tonsils using CD4 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Negative control was used by secondary antibody only.
	Immunohistochemistry analysis of paraffin-embedded mouse brain tissue using CD4 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Negative control was used by secondary antibody only.
	Immunohistochemistry analysis of paraffin-embedded Human Amygdala using CD4 antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.