Mouse Monoclonal Antibody to Cyclin H

包装: 1G|100G|500G|1KG|100KG

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别名:CCNH; Cyclin-H; MO15-associated protein; p34; p37
应用:WB,IP
反应种属:Human
规格：50μl/100μl

Description
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Description

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Specification
Aliases	CCNH; Cyclin-H; MO15-associated protein; p34; p37
Entrez GeneID	902
Swissprot	P51946
clone	3B10
WB Predicted band size	Calculated MW: 38 kDa; Observed MW: 38 kDa
Host/Isotype	Mouse IgG2b
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant human Cyclin H protein fragments expressed in E.coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IP	1/20
WB	1/500-1/1000

	Western blot analysis of Cyclin H in Jurkat, K562 and A431 lysates using Cyclin H antibody.
	Immunoprecipitation analysis of Cyclin H in Hela lysates using Cyclin H antibody.