Mouse Monoclonal Antibody to DDR2(Ascites)

包装: 1G|100G|500G|1KG|100KG

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别名:Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5′ UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq].

Description

Receptor tyrosine kinases (RTKs) play a key role in the
communication of cells with their microenvironment. These molecules
are involved in the regulation of cell growth, differentiation, and
metabolism. In several cases the biochemical mechanism by which
RTKs transduce signals across the membrane has been shown to be
ligand induced receptor oligomerization and subsequent
intracellular phosphorylation. This autophosphorylation leads to
phosphorylation of cytosolic targets as well as association with
other molecules, which are involved in pleiotropic effects of
signal transduction. RTKs have a tripartite structure with
extracellular, transmembrane, and cytoplasmic regions. This gene
encodes a member of a novel subclass of RTKs and contains a
distinct extracellular region encompassing a factor VIII-like
domain. Alternative splicing in the 5′ UTR results in multiple
transcript variants encoding the same protein. [provided by
RefSeq].

Specification
Aliases	Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10
Entrez GeneID	4921
Swissprot	Q16832
WB Predicted band size	96.7kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This DDR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2.
Formulation	Mouse monoclonal antibody supplied in crude ascites with 0.05% sodium azide.

Application
WB	1/100-1/1600

	DDR2 Antibody (Cat. #P31911) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the DDR2 antibody detected the DDR2 protein (arrow).
	Immunohistochemical analysis of paraffin-embedded Human lung section using Pink1(Cat#am2058a). am2058a was diluted at 1:200 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.