Mouse Monoclonal Antibody to DKK2

包装: 1G|100G|500G|1KG|100KG

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别名:Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Description

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Specification
Aliases	Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2
Entrez GeneID	27123
Swissprot	Q9UBU2
WB Predicted band size	28.4kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.