中文 
别名:DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, 2.1.1.37, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl
| Description |
|---|
| Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated ‘Lys-36’ of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
| Specification | |
|---|---|
| Aliases | DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, 2.1.1.37, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A |
| Entrez GeneID | 1788 |
| Swissprot | Q9Y6K1 |
| WB Predicted band size | 101.9kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Dnmt3a antibody is generated from a mouse immunized with a recombinant protein of human Dnmt3a. |
| Application | |
|---|---|
| WB | 1/2000-1/4000 |
 |
All lanes : Anti-Dnmt3a Antibody at 1:2000-1:4000 dilution Lane 1: T47D whole cell lysate Lane 2: CCRF-CEM whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Predicted band size : 102 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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