Mouse Monoclonal Antibody to HDAC6

包装: 1G|100G|500G|1KG|100KG

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别名:HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
应用:WB
反应种属:Human,Rat
规格：50μl/100μl

Description
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Description

Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Specification
Aliases	HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
Entrez GeneID	10013
Swissprot	Q9UBN7
clone	3A2
WB Predicted band size	Calculated MW: 131 kDa; Observed MW: 160 kDa
Host/Isotype	Mouse IgG2a
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat
Immunogen	Purified recombinant human HDAC6 protein expressed in E.coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.