Mouse Monoclonal Antibody to JAK2

包装: 1G|100G|500G|1KG|100KG

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别名:JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
应用:IHC
反应种属:Human,Rat,Mouse
规格：50μl/100μl

Description
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Description

Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Specification
Aliases	JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Entrez GeneID	3717
Swissprot	O60674
clone	3A7
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat,Mouse
Immunogen	Synthetic peptide conjugated to KLH.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IHC	1/50-1/100

	Immunohistochemistry analysis of paraffin-embedded Human Breast Carcinoma Tissue using JAK2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
	Immunohistochemical analysis of paraffin-embedded Human tonsils using JAK2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.