Mouse Monoclonal Antibody to KDM1A

包装: 1G|100G|500G|1KG|100KG

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别名:KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2
应用:WB,ICC,IP
反应种属:Human,Monkey
规格：50μl/100μl

Description
Histone demethylase that demethylates both ‘Lys-4’ (H3K4me) and ‘Lys-9’ (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

Description

Histone demethylase that demethylates both ‘Lys-4’ (H3K4me) and ‘Lys-9’ (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

Specification
Aliases	KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2
Entrez GeneID	23028
Swissprot	O60341
clone	2F6
WB Predicted band size	Calculated MW: 93 kDa; Observed MW: 110 kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Monkey
Immunogen	Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IP	1/20
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of KDM1/LSD1 in Hela, HCT116 and COS7 lysates using KDM1/LSD1 antibody.
	Immunoprecipitation analysis of KDM1A in Hela lysates using KDM1/LSD1 antibody.
	Immunocytochemistry analysis of KDM1A in HeLa using KDM1/LSD1 antibody.