Mouse Monoclonal Antibody to Ku70

包装: 1G|100G|500G|1KG|100KG

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别名:XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
应用:WB,ICC
反应种属:Human
规格：50μl/100μl

Description
It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.

Description

It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.

Specification
Aliases	XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
Entrez GeneID	2547
Swissprot	P12956
clone	2F5
WB Predicted band size	Calculated MW: 70 kDa; Observed MW: 70 kDa
Host/Isotype	Mouse IgG2b
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant human Ku70 protein fragments expressed in E.coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of Ku70 in Hela, A549, MCF-7, Jurkat and Raji lysates using Ku70 antibody.
	Immunocytochemistry analysis of Ku70 in HeLa using Ku70 antibody.