Mouse Monoclonal Antibody to Ku70

包装: 1G|100G|500G|1KG|100KG

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别名:XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
应用:WB,ICC,IP
反应种属:Human,Monkey
规格：50μl/100μl

Description
It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.

Description

It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.

Specification
Aliases	XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
Entrez GeneID	2547
Swissprot	P12956
clone	7A1
WB Predicted band size	Calculated MW: 70 kDa; Observed MW: 67 kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Monkey
Immunogen	Purified recombinant human Ku70 protein fragments expressed in E.coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IP	1/20
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of Ku70 in Hela, A549, COS7 and K562 lysates using Ku70 antibody.
	Immunoprecipitation analysis of Ku70 in Hela lysates using Ku7 antibody.
	Immunocytochemistry analysis of Ku70 in HeLa using Ku70 antibody.