中文 
别名:Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2应用:WB
反应种属:Human, Mouse
规格：50μl/100μl
| Description |
|---|
| Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5′-GGAG-3′ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5′-GGAG-3′ motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. |
| Specification | |
|---|---|
| Aliases | Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2 |
| Entrez GeneID | 389421 |
| Swissprot | Q6ZN17 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LIN28B antibody is generated from a mouse immunized with a recombinant protein of human LIN28B. |
| Application | |
|---|---|
| WB | 1/2000 |
 |
All lanes : Anti-LIN28B Antibody at 1:4000 dilution Lane 1: 293 whole cell lysate Lane 2: K562 whole cell lysate Lane 3: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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