Mouse Monoclonal Antibody to MB21D1

包装: 1G|100G|500G|1KG|100KG

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别名:Cyclic GMP-AMP synthase, cGAMP synthase, cGAS, h-cGAS, 2.7.7.86, Mab-21 domain-containing protein 1, MB21D1, C6orf150
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2′,5′ phosphodiester linkage at the GpA step and the formation of a 3′,5′ phosphodiester linkage at the ApG step, producing c[G(2′,5′)pA(3′,5′)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Description

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2′,5′ phosphodiester linkage at the GpA step and the formation of a 3′,5′ phosphodiester linkage at the ApG step, producing c[G(2′,5′)pA(3′,5′)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Specification
Aliases	Cyclic GMP-AMP synthase, cGAMP synthase, cGAS, h-cGAS, 2.7.7.86, Mab-21 domain-containing protein 1, MB21D1, C6orf150
Entrez GeneID	115004
Swissprot	Q8N884
WB Predicted band size	58.8kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This MB21D1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-185 amino acids from human MB21D1.