Mouse Monoclonal Antibody to Phospho-ERK1/2 (Tyr222/Tyr205)

包装: 1G|100G|500G|1KG|100KG

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别名:MAPK1/MAPK3
应用:IHC
反应种属:Human,Rat,Mouse
规格：50μl/100μl

Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

Description

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

Specification
Aliases	MAPK1/MAPK3
Entrez GeneID	5595/5594
Swissprot	P27361/P28482
clone	5F8
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat,Mouse
Immunogen	Synthetic peptide conjugated to KLH.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IHC	1/50-1/100

	Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using Phospho-ERK1/2 (Tyr222/Tyr205) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
	Immunohistochemical analysis of paraffin-embedded Human tonsils using Phospho-ERK1/2 (Tyr222/Tyr205) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.