Mouse Monoclonal Antibody to PPP4C

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别名:PP4; PPX; PP4C; PPH3; PPP4
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.

Description

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.

Specification
Aliases	PP4; PPX; PP4C; PPH3; PPP4
Entrez GeneID	5531
Swissprot	P60510
clone	2H8
WB Predicted band size	Calculated MW: 35 kDa; Observed MW: 35 kDa
Host/Isotype	Mouse IgG2a
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of Protein Phosphatase 4C in Hela and Jurkat lysates using Protein Phosphatase 4C antibody.
	Immunocytochemistry analysis of PPP4C in HeLa cells using PPP4C antibody.
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Protein Phosphatase 4C antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.