Mouse Monoclonal Antibody to SMARCA2

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别名:BIS;BRM;SNF2;SWI2;hBRM;NCBRS;Sth1p;BAF190;SNF2L2;SNF2LA;hSNF2a
应用:WB,IHC,ICC,FCM
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

Description

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

Specification
Aliases	BIS;BRM;SNF2;SWI2;hBRM;NCBRS;Sth1p;BAF190;SNF2L2;SNF2LA;hSNF2a
Entrez GeneID	6595
Swissprot	P51531
clone	3A7B4
WB Predicted band size	181.3kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
WB	1/500-1/1000
IHC	1/200-1/400
ICC	1/25-1/50
FCM	1/200 – 1/400

	Western blot analysis using SMARCA2 mouse mAb against Hela(1),HEK293(2),HepG2(3),A431(4)cell lysate.
	Confocal Immunofluorescence analysis of NIH3T3 cells using SMARCA2 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
	Flow cytometric analysis of Hela cells using SMARCA2 mouse mAb (green) and negative control (red).
	Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SMARCA2 mouse mAb with DAB staining.
	Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using SMARCA2 mouse mAb with DAB staining.