中文 
别名:NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1应用:WB,IP
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. |
| Specification | |
|---|---|
| Aliases | NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1 |
| Entrez GeneID | 8883 |
| Swissprot | Q13564 |
| WB Predicted band size | Calculated MW: 60 kDa; Observed MW: 60 kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human APPBP1 |
| Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Application | |
|---|---|
| IP | 1/20 |
| WB | 1/500-1/1000 |
 |
Western blot analysis of APPBP1 in SKOV-3 lysates using APPBP1 antibody. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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