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瑞威尔生物科技 REVERE

Rabbit Monoclonal Antibody to ARFGEF2

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别名:BIG2; PVNH2; dJ1164I10.1
应用:WB
反应种属:Human,Mouse,Rat
规格:50μl/100μl

Description
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
Specification
Aliases BIG2; PVNH2; dJ1164I10.1
Entrez GeneID 10564
Swissprot Q9Y6D5
WB Predicted band size Calculated MW: 202 kDa; Observed MW: 202 kDa
Host/Isotype Rabbit IgG
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen A synthetic peptide of human ARFGEF2
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Application
WB 1/500-1/1000

Western blot analysis of ARFGEF2/BIG2 in rat testis lysates using ARFGEF2 antibody.
Western blot analysis of ARFGEF2 in Hela, 293T lysates using ARFGEF2 antibody.

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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。