Rabbit Monoclonal Antibody to ATP6V0D1

包装: 1G|100G|500G|1KG|100KG

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别名:P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD
应用:WB,IHC,ICC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis . May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

Description

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis . May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

Specification
Aliases	P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD
Entrez GeneID	9114
Swissprot	P61421
WB Predicted band size	Calculated MW: 40 kDa; Observed MW: 40 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Recombinant protein of human ATP6V0D1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of ATP6V0D1 in K562, rat Brain, C6, 3T3, Hela lysates using ATP6V0D1 antibody.
	Immunocytochemistry analysis of ATP6V0D1(green) in Hela using ATP6V0D1 antibody,and DAPI(blue)
	Immunohistochemistry analysis of paraffin-embedded Human colon cancer using ATP6V0D1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.