Rabbit Monoclonal Antibody to Caspase 11

包装: 1G|100G|500G|1KG|100KG

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别名:Caspl; ich-3; CASP-4; Casp11; CASP-11
应用:WB,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.

Description

Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.

Specification
Aliases	Caspl; ich-3; CASP-4; Casp11; CASP-11
Entrez GeneID	12363
Swissprot	P70343
WB Predicted band size	Calculated MW: 43 kDa; Observed MW: 43,38,25 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Recombinant protein of mouse Caspase-11
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA