Rabbit Monoclonal Antibody to CDKN2A/p16INK4a

包装: 1G|100G|500G|1KG|100KG

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别名:Cdkn2a;P16ink4a;Cyclin-dependent kinase 4 inhibitor A (CDK4I);p16-INK4a ;p16-INK4
应用:WB,ICC,IP
反应种属:Mouse,Rat
规格：50μl/100μl

Description
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.CautionThe proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q64364) which is encoded by the same gene.

Description

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.CautionThe proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q64364) which is encoded by the same gene.

Specification
Aliases	Cdkn2a;P16ink4a;Cyclin-dependent kinase 4 inhibitor A (CDK4I);p16-INK4a ;p16-INK4
Entrez GeneID	12578
Swissprot	P51480
WB Predicted band size	Calculated MW: 18 kDa; Observed MW: 18 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Mouse,Rat
Immunogen	Recombinant protein of mouse CDKN2A/p16INK4a
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of CDKN2A/p16INK4a in 3T3 lysates using CDKN2A antibody.
	Western blot analysis of CDKN2A/p16INK4a in C6 lysates using CDKN2A/p16INK4a antibody.