Rabbit Monoclonal Antibody to CLIC4

包装: 1G|100G|500G|1KG|100KG

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别名:CLIC4; Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1
应用:WB,IHC,ICC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Description

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Specification
Aliases	CLIC4; Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1
Entrez GeneID	25932
Swissprot	Q9Y696
WB Predicted band size	Calculated MW: 29 kDa; Observed MW: 29 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human CLIC4
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of CLIC4 in rat Brain, C6, 3T3, Hela lysates using CLIC4 antibody.
	Immunocytochemistry analysis of CLIC4(green) in Hela using CLIC4 antibody,and DAPI(blue)
	Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using CLIC4 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.