Rabbit Monoclonal Antibody to Cyclooxygenase 2

包装: 1G|100G|500G|1KG|100KG

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别名:COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Description

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Specification
Aliases	COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
Entrez GeneID	5743
Swissprot	P35354
WB Predicted band size	Calculated MW: 69 kDa; Observed MW: 69 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human COX2
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of COX2/cyclooxygenase2 in rat Brain lysates using Cyclooxygenase 2 antibody.
	Immunohistochemistry analysis of paraffin-embedded Human lung cancer using COX2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.