Rabbit Monoclonal Antibody to HDAC2

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别名:HDAC2; Histone deacetylase 2; HD2
应用:WB,IHC,ICC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA.

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA.

Specification
Aliases	HDAC2; Histone deacetylase 2; HD2
Entrez GeneID	3066
Swissprot	Q92769
WB Predicted band size	Calculated MW: 55 kDa; Observed MW: 60 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Recombinant protein of human HDAC2
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of HDAC2 in K562, C6, 3T3 lysates using HDAC2 antibody.
	Immunocytochemistry analysis of HDAC2(green) in Hela using HDAC2 antibody,and DAPI(blue)
	Immunohistochemistry analysis of paraffin-embedded Human colon cancer using HDAC2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.