Rabbit Monoclonal Antibody to HP1 gamma

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别名:HECH; HP1-GAMMA; HP1Hs-gamma; CBX3
应用:WB,IHC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ‘Lys-9’, leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ‘Lys-9’ trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Description

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ‘Lys-9’, leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ‘Lys-9’ trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Specification
Aliases	HECH; HP1-GAMMA; HP1Hs-gamma; CBX3
Entrez GeneID	12417
Swissprot	P23198
WB Predicted band size	Calculated MW: 21 kDa; Observed MW: 21 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of mouse HP1 gamma
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of HP1 gamma in K562, C6, 3T3 lysates using HP1 gamma antibody.
	Immunohistochemistry analysis of paraffin-embedded Human colon cancer using HP1 gamma antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.