Rabbit Monoclonal Antibody to Insulin Degrading Enzyme

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别名:INSULYSIN; Insulin degrading enzyme; IDE
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid.

Description

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid.

Specification
Aliases	INSULYSIN; Insulin degrading enzyme; IDE
Entrez GeneID	3416
Swissprot	P14735
WB Predicted band size	Calculated MW: 118 kDa; Observed MW: 118 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human IDE
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of Insulin Degrading Enzyme/IDE in Hela, A549, HL-60, U2OS lysates using Insulin Degrading Enzyme antibody.
	Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Insulin Degrading Enzyme/IDE antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.