Rabbit Monoclonal Antibody to IRF8

包装: 1G|100G|500G|1KG|100KG

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别名:ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
应用:WB,IHC,IP
反应种属:Human
规格：50μl/100μl

Description
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .

Description

Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .

Specification
Aliases	ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
Entrez GeneID	3394
Swissprot	Q02556
WB Predicted band size	Calculated MW: 48 kDa; Observed MW: 48 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Recombinant protein of human IRF8
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA