Rabbit Monoclonal Antibody to ITPA

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别名:My049; ITPase; NTPase; C20orf37; dJ794I6.3; HLC14-06-P
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2′-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5′-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Description

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2′-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5′-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Specification
Aliases	My049; ITPase; NTPase; C20orf37; dJ794I6.3; HLC14-06-P
Entrez GeneID	3704
Swissprot	Q9BY32
WB Predicted band size	Calculated MW: 21 kDa; Observed MW: 21 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthetic peptide of human Inosine triphosphate pyrophosphatase
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of ITPA in Hela lysates using ITPA antibody.
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Inosine triphosphate pyrophosphatase antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.