Rabbit Monoclonal Antibody to KIF5B

包装: 1G|100G|500G|1KG|100KG

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别名:KNS; KINH; KNS1; UKHC; HEL-S-61
应用:WB,IHC,ICC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner . Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation .

Description

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner . Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation .

Specification
Aliases	KNS; KINH; KNS1; UKHC; HEL-S-61
Entrez GeneID	3799
Swissprot	P33176
WB Predicted band size	Calculated MW: 110 kDa; Observed MW: 110 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human KIF5B
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of KIF5B in mouse brain, rat brain lysates using KIF5B antibody.
	Western blot analysis of KIF5B in Hela, MCF-7, U251MG, K562 lysates using KIF5B antibody.
	Immunocytochemistry analysis of KIF5B (green) in Hela using KIF5B antibody,and DAPI(blue).
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer using KIF5B antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.