Rabbit Monoclonal Antibody to Lamin A/C

包装: 1G|100G|500G|1KG|100KG

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别名:LMNA; LMN1; Prelamin-A/C
应用:WB,IHC,ICC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Description

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Specification
Aliases	LMNA; LMN1; Prelamin-A/C
Entrez GeneID	4000
Swissprot	P02545
WB Predicted band size	Calculated MW: 74 kDa; Observed MW: 74,63 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human Lamin A/C
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of Lamin A/C in rat heart, rat skeletal muscle lysates using Lamin A/C antibody.
	Western blot analysis of Lamin A/C in 3T3, Hela lysates using Lamin A/C antibody.
	Immunocytochemistry analysis of Lamin A/C(green) in Hela using Lamin A/C antibody,and DAPI(blue)
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.