Rabbit Monoclonal Antibody to LXR alpha

包装: 1G|100G|500G|1KG|100KG

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别名:NR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
应用:WB,IHC
反应种属:Human,Rat
规格：50μl/100μl

Description
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Description

Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Specification
Aliases	NR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
Entrez GeneID	10062
Swissprot	Q13133
WB Predicted band size	Calculated MW: 50 kDa; Observed MW: 50 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat
Immunogen	A synthetic peptide of human LXR alpha
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of LXR alpha in Jurkat lysates using LXR alpha antibody.
	Western blot analysis of LXR alpha in rat Brain lysates using LXR alpha antibody.
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer using LXR alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.