Rabbit Monoclonal Antibody to MEF2A

包装: 1G|100G|500G|1KG|100KG

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别名:mef2; ADCAD1; RSRFC4; RSRFC9
应用:WB,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Transcriptional activator which binds specifically to the MEF2 element, 5′-YTA[AT]4TAR-3′, found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Description

Transcriptional activator which binds specifically to the MEF2 element, 5′-YTA[AT]4TAR-3′, found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Specification
Aliases	mef2; ADCAD1; RSRFC4; RSRFC9
Entrez GeneID	4205
Swissprot	Q02078
WB Predicted band size	Calculated MW: 55 kDa; Observed MW: 55 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human MEF2A
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of MEF2A in K562, rat Brain, C6, 3T3, Hela lysates using MEF2A antibody.
	Immunocytochemistry analysis of MEF2A (green) in MCF-7 using MEF2A antibody,and DAPI(blue)