Rabbit Monoclonal Antibody to MLH1

包装: 1G|100G|500G|1KG|100KG

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别名:MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1
应用:WB,ICC,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined.

Description

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined.

Specification
Aliases	MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1
Entrez GeneID	4292
Swissprot	P40692
WB Predicted band size	Calculated MW: 85 kDa; Observed MW: 85 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human MLH1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of MLH1 in K562, C6, 3T3, Hela lysates using MLH1 antibody.
	Immunocytochemistry analysis of MLH1(green) in Hela using MLH1 antibody,and DAPI(blue)