Rabbit Monoclonal Antibody to MTHFR

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别名:MTHFR; Methylenetetrahydrofolate reductase
应用:WB,ICC,IP
反应种属:Human,Mouse
规格：50μl/100μl

Description
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Description

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Specification
Aliases	MTHFR; Methylenetetrahydrofolate reductase
Entrez GeneID	4524
Swissprot	P42898
WB Predicted band size	Calculated MW: 75 kDa; Observed MW: 75 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Recombinant protein of human MTHFR
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
ICC	1/50-1/200

	Western blot analysis of MTHFR in 3T3, Raw264.7 lysates using MTHFR antibody.
	Western blot analysis of MTHFR in K562 lysates using MTHFR antibody
	Immunocytochemistry analysis of MTHFR (green) in K562 using MTHFR antibody,and DAPI(blue).