Rabbit Monoclonal Antibody to PHD1

包装: 1G|100G|500G|1KG|100KG

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别名:Estrogen-induced tag 6; HPH-3; PHD1
应用:WB
反应种属:Human,Rat
规格：50μl/100μl

Description
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Description

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Specification
Aliases	Estrogen-induced tag 6; HPH-3; PHD1
Entrez GeneID	112398
Swissprot	Q96KS0
WB Predicted band size	Calculated MW: 44 kDa; Observed MW: 44 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat
Immunogen	A synthesized peptide derived from human PHD1/prolyl hydroxylase
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000

	Western blot analysis of PHD1/prolyl hydroxylase in rat heart lysates using PHD1 antibody.
	Western blot analysis of PHD1/prolyl hydroxylase in Hela, A549, HL-60, U2OS, U87-MG lysates using PHD1/prolyl hydroxylase antibody.