Rabbit Monoclonal Antibody to Phospho-ERK1/2 (Thr202/Thr185)

包装: 1G|100G|500G|1KG|100KG

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别名:MAPK1/MAPK3
应用:WB,IP
反应种属:Human,Rat
规格：50μl/100μl

Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

Description

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

Specification
Aliases	MAPK1/MAPK3
Entrez GeneID	5595/5594
Swissprot	P27361/P28482
WB Predicted band size	Calculated MW: 44,42 kDa; Observed MW: 44,42 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Thr202 of human ERK1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000

	Western blot analysis of Phospho-ERK1 (Thr202)/ERK2 (Thr185) in Hela, Hela+TPA, C6, C6+TPA lysates using Phospho-ERK1/2 (Thr202/Thr185) antibody.
	Western blot analysis of Phospho-p44/42 MAPK (ERK1/2) (Thr202) in C6, Hela lysates using Phospho-p44/42 MAPK (ERK1/2) (Thr202) antibody.