Rabbit Monoclonal Antibody to Phospho-mTOR (Ser2448)

包装: 1G|100G|500G|1KG|100KG

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别名:MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

Specification
Aliases	MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar
Entrez GeneID	2475
Swissprot	P42345
WB Predicted band size	Calculated MW: 289 kDa; Observed MW: 289 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Ser2448 of human mTOR
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of Phospho-mTOR (Ser2448) in Hela, Hela+EGF lysates using Phospho-mTOR (Ser2448) antibody.
	Western blot analysis of mTOR (Phospho-Ser2448) in 3t3 lysates using mTOR (Phospho-Ser2448) antibody.
	Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Phospho-mTOR (Ser2448) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.