Rabbit Monoclonal Antibody to Phospho-PML Protein (Ser518)

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别名:PML; MYL; RNF71; TRIM19; Protein PML; Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Regulates RB1 phosphorylation and activity. Required for normal development of the brain cortex during embryogenesis. Can sequester herpes virus and varicella virus proteins inside PML bodies, and thereby inhibit the formation of infectious viral particles. Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum (By similarity). Regulates transcription activity of ELF4.

Description

Regulates RB1 phosphorylation and activity. Required for normal development of the brain cortex during embryogenesis. Can sequester herpes virus and varicella virus proteins inside PML bodies, and thereby inhibit the formation of infectious viral particles. Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum (By similarity). Regulates transcription activity of ELF4.

Specification
Aliases	PML; MYL; RNF71; TRIM19; Protein PML; Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19
Entrez GeneID	5371
Swissprot	P29590
WB Predicted band size	Calculated MW: 98 kDa; Observed MW: 98,117 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of Phospho-PML Protein (Ser518) in A549, HL-60, U2OS lysates using Phospho-PML Protein (Ser518) antibody.
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer using PML Protein (Phospho-Ser518) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.