Rabbit Monoclonal Antibody to Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177)

包装: 1G|100G|500G|1KG|100KG

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别名:DPK; JIK; hKFC-A; MAP3K18
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.

Description

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.

Specification
Aliases	DPK; JIK; hKFC-A; MAP3K18
Entrez GeneID	51347/57551/9344
Swissprot	Q7L7X3/Q9H2K8/Q9UL54
WB Predicted band size	Calculated MW: 116 kDa; Observed MW: 105,116,138 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of Phospho-TAOK1(Ser181)/TAOK2 (Ser181)/TAOK3 (Ser177) in 3T3 lysates using Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) antibody.
	Western blot analysis of TAOK1 (Phospho-Ser181)/TAOK2 (Phospho-Ser181)/TAOK3 (Phospho-Ser177) in Hela, A549, HL-60, U2OS, C6 lysates using TAOK1 (Phospho-Ser181)/TAOK2 (Phospho-Ser181)/TAOK3 (Phospho-Ser177) antibody.
	Immunohistochemistry analysis of paraffin-embedded Human tonsil using TAOK1 (Phospho-Ser181)/TAOK2 (Phospho-Ser181)/TAOK3 (Phospho-Ser177) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.