Rabbit Monoclonal Antibody to SQSTM1/p62

包装: 1G|100G|500G|1KG|100KG

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别名:p60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3
应用:WB,IHC,ICC,IP
反应种属:Human,Mouse
规格：50μl/100μl

Description
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.

Description

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.

Specification
Aliases	p60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3
Entrez GeneID	8878
Swissprot	Q13501
WB Predicted band size	Calculated MW: 48 kDa; Observed MW: 62 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Recombinant protein of human SQSTM1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of SQSTM1 in K562, 3T3, Hela lysates using SQSTM1 antibody.
	Immunocytochemistry analysis of SQSTM1/p62 (green) in U87-MG using SQSTM1/p62 antibody,and DAPI(blue).
	Immunohistochemistry analysis of paraffin-embedded Human breast cancer tissue using SQSTM1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.