Rabbit Polyclonal Antibody to 4E BP1

包装: 1G|100G|500G|1KG|100KG

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别名:EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
应用:WB,IP
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

Specification
Aliases	EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Entrez GeneID	1978
Swissprot	Q13541
WB Predicted band size	Calculated MW: 13 kDa; Observed MW: 15-20 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
IP	1/20
WB	1/500-1/1000

	Western blot analysis of 4EBP1 in SH-SY5Y, C2C12 and 3T3 lysates using 4EBP1 antibody.
	Western blot analysis of 4E BP1 in Jurkat, Hela and C6 lysates using 4EBP1 antibody.
	Western blot analysis of 4E BP1 in C2C12, A549 and 3T3 lysates using 4E BP1 antibody
	Immunoprecipitation analysis of 4E BP1 in Hela lysates using 4EBP1 antibody.