Rabbit Polyclonal Antibody to 53BP1 (phospho Ser6)

包装: 1G|100G|500G|1KG|100KG

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别名:TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1
应用:WB,IHC
反应种属:Human,Mouse,Rat,Monkey
规格：50μl/100μl

Description
function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at ‘Lys-20’ is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on ‘Ser-139’. Interacts with histone H4 that has been dimethylated at ‘Lys-20’. Has low affinity for histone H4 containing monomethylated ‘Lys-20’. Does not bind histone H4 containing unmethylated or trimethylated ‘Lys-20’. Has low affinity for histone H3 that has been dimethylated on ‘Lys-79’. Has very low affinity for histone H3 that has been monomethylated on ‘Lys-79’ (in vitro). Does not bind unmethylated histone H3.,

Description

function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at ‘Lys-20’ is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on ‘Ser-139’. Interacts with histone H4 that has been dimethylated at ‘Lys-20’. Has low affinity for histone H4 containing monomethylated ‘Lys-20’. Does not bind histone H4 containing unmethylated or trimethylated ‘Lys-20’. Has low affinity for histone H3 that has been dimethylated on ‘Lys-79’. Has very low affinity for histone H3 that has been monomethylated on ‘Lys-79’ (in vitro). Does not bind unmethylated histone H3.,

Specification
Aliases	TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1
Entrez GeneID	7158
Swissprot	Q12888
WB Predicted band size	213kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat,Monkey
Immunogen	The antiserum was produced against synthesized peptide derived from human 53BP1 around the phosphorylation site of Ser6. AA range:1-50
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.