Rabbit Polyclonal Antibody to ABCB11

包装: 1G|100G|500G|1KG|100KG

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别名:BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
应用:IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Specification
Aliases	BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
Swissprot	O95342
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human ABCB11
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/15-1/50
ELISA	1/1000-1/5000

	The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11159(ABCB11 Antibody) at dilution 1/15. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P11159(ABCB11 Antibody) at dilution 1/15. (Original magnification: ×200)