中文 
别名:MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. |
| Specification | |
|---|---|
| Aliases | MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145 |
| Entrez GeneID | 10057; |
| Swissprot | O15440 |
| WB Predicted band size | 161kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to residues near the N terminal of human ATP-binding cassette, sub-family C? |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| WB | 1/1000-1/5000 |
| IHC | 1/50-1/200 |
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Gel: 10%SDS-PAGE Lysates (from left to right): Mouse heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/950 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 minutes |
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Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using P42868 at dilution 1/50. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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