中文 
别名:Abelson murine leukemia viral oncogene 1; ABL1; c-ABL; JTK7; p150应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. Fainstein E., Oncogene 4:1477-1481(1989)Shtivelman E., Cell 47:277-284(1986)Chissoe S.L., Genomics 27:67-82(1995). |
| Specification | |
|---|---|
| Aliases | Abelson murine leukemia viral oncogene 1; ABL1; c-ABL; JTK7; p150 |
| Entrez GeneID | 25; |
| Swissprot | P00519 |
| WB Predicted band size | 135kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of threonine735 (S-V-T(p)-L-P) derived from Human ABL1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from COS cells treated with EGF using ABL1 (Phospho-Thr735) Antibody P40429.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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