Rabbit Polyclonal Antibody to ACIN1

包装: 1G|100G|500G|1KG|100KG

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别名:ACN; ACINUS; fSAP152
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Specification
Aliases	ACN; ACINUS; fSAP152
Entrez GeneID	22985;
Swissprot	Q9UKV3
WB Predicted band size	152kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthetic peptide corresponding to a region derived from internal residues of human apoptotic chromatin condensation inducer 1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/25-1/100

	Gel: 8%SDS-PAGE Lysate: 40ug 231 cell Primary antibody: 1/550 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute
	Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using P42839 at dilution 1/30.