Rabbit Polyclonal Antibody to AIM2

包装: 1G|100G|500G|1KG|100KG

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别名:Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 By similarity. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.DeYoung K.L., Oncogene 15:453-457(1997).Gregory S.G., Nature 441:315-321(2006).

Description

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 By similarity. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.DeYoung K.L., Oncogene 15:453-457(1997).Gregory S.G., Nature 441:315-321(2006).

Specification
Aliases	Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2;
Entrez GeneID	9447;
Swissprot	O14862
WB Predicted band size	39kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human AIM2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.