Rabbit Polyclonal Antibody to AIM2

包装: 1G|100G|500G|1KG|100KG

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别名:PYHIN4
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-?, AIM2 is thought to act as a tumor suppressor by repressing NF?B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of ?-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.

Description

Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-?, AIM2 is thought to act as a tumor suppressor by repressing NF?B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of ?-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.

Specification
Aliases	PYHIN4
Entrez GeneID	9447;
Swissprot	O14862
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to a region derived from internal residues of human absent in melanoma 2
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
IHC	1/50-1/200

	Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using P42809 at dilution 1/60.
	Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using P42809 at dilution 1/60.