Rabbit Polyclonal Antibody to AIRE

包装: 1G|100G|500G|1KG|100KG

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别名:Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein, AIRE, APECED
应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Description

This gene encodes a transcriptional regulator that forms
nuclear bodies and interacts with the transcriptional coactivator
CBP. At least three splice variant mRNAs products have been
described including one which results in a premature stop codon and
a transcript predicted to be a candidate for nuclear-mediated decay
(NMD). Defects in this gene cause the rare autosomal-recessive
systemic autoimmune disease termed autoimmune
polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Specification
Aliases	Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein, AIRE, APECED
Entrez GeneID	326
Swissprot	O43918
WB Predicted band size	57.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	This AIRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/2000

All lanes : Anti-AIRE Antibody (Center) at 1:2000 dilution
Lane 1: Hela whole cell lysate
Lane 2: U-20S whole cell lysate
Lane 3: K562 whole cell lysate
Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/2000 dilution.

Predicted band size : 58 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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