Rabbit Polyclonal Antibody to AKR1C1

包装: 1G|100G|500G|1KG|100KG

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别名:Aldo-keto reductase family 1, member C1, C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD
应用:WB,IHC
反应种属:Human,Rat
规格：50μl/100μl

Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Description

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Specification
Aliases	Aldo-keto reductase family 1, member C1, C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD
Entrez GeneID	1645;
Swissprot	Q04828
WB Predicted band size	37kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Rat
Immunogen	Synthetic peptide corresponding to a region derived from 290-304 amino acids of human aldo-keto reductase family 1, member C1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/50-1/200
ELISA	1:2000-1:5000

	Gel: 10%SDS-PAGE Lane1: Human liver cancer tissue lysate Lane2: Human breast infiltrative duct tissue lysate Lane3: Human fetal brain tissue lysate Lysate: 27ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG – H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes
	The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using 31278 (AKR1C1 Antibody) at dilution 1/30, on the right is treated with the synthetic peptide.