Rabbit Polyclonal Antibody to AKR1C2

包装: 1G|100G|500G|1KG|100KG

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别名:Aldo-keto reductase family 1 member C2, 1—, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Description

This gene encodes a member of the aldo/keto reductase
superfamily, which consists of more than 40 known enzymes and
proteins. These enzymes catalyze the conversion of aldehydes and
ketones to their corresponding alcohols using NADH and/or NADPH as
cofactors. The enzymes display overlapping but distinct substrate
specificity. This enzyme binds bile acid with high affinity, and
shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This
gene shares high sequence identity with three other gene members
and is clustered with those three genes at chromosome 10p15-p14.

Specification
Aliases	Aldo-keto reductase family 1 member C2, 1—, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2
Entrez GeneID	1646
Swissprot	P52895
WB Predicted band size	36.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human AKR1C2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	AKR1C2 Antibody (C-term) (Cat. #P31058) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the AKR1C2 antibody detected the AKR1C2 protein (arrow).
	AKR1C2 Antibody (C-term) (Cat. #P31058)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AKR1C2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.